Since its creation in 2011, the Canadian Network for Observational Drug Effect Studies (CNODES) has built a network of over 100 scientists to ensure the safety and effectiveness of drugs for Canadians. CNODES has obtained access to administrative healthcare data on millions of medication users across Canada and internationally. CNODES uses state of the art methods of observational research, as well as rapid-response studies using semi-automated tools and a common data model (CDM) for standardized analyses.