Since its creation in 2011, the Canadian Network for Observational Drug Effect Studies (CNODES) has built a network of over 100 scientists to ensure the safety and effectiveness of drugs for Canadians. CNODES has obtained access to administrative healthcare data on millions of medication users across Canada and internationally. CNODES uses state of the art methods of observational research, as well as rapid-response studies using semi-automated tools and a common data model (CDM) for standardized analyses.


Current Publications

Prescription ranitidine use and population exposure in 6 Canadian provinces, 1996 to 2019: a serial cross-sectional analysis Levy AR, Stock D, Paterson JM, et al. CMAJ Open. 2023;11(6):E1033-E1040.
Hydrochlorothiazide use and risk of keratinocyte carcinoma and melanoma: A multisite population-based cohort study Azoulay L, St-Jean A, Dahl M, et al. J Am Acad Dermatol. 2023;89(2):243-253.
Exploring female parity in pharmacoepidemiology authorship: A case study of the Canadian Network for Observational Drug Effect Studies and its citing articles. Sketris IS, Traynor RL, Helwig M, et al. Pharmacoepidemiol Drug Saf. 2022 Jan;31(1):82-90.
Defining the duration of the dispensation of oral anticoagulants in administrative healthcare databases. Sinyavskaya L, Renoux C, Durand M. Pharmacoepidemiol Drug Saf. 2022 Jan;31(1):105-109.

Project Findings

Sodium-glucose co-transporter-2 inhibitors and the risk of urosepsis: A multi-site, prevalent new-user cohort study
SGLT2 inhibitors do not increase the risk of severe urinary tract infection in patients with type 2 diabetes
Effectiveness and safety among direct oral anticoagulants in nonvalvular atrial fibrillation: A multi-database cohort study with meta-analysis
Apixaban decreases the risks of stroke and bleeding in patients with atrial fibrillation
Off-label postpartum use of domperidone in Canada: a multidatabase cohort study
Reduced postpartum domperidone use after Health Canada advisories
Reliability of COVID-19 case definitions in administrative and clinical databases
Reliability of COVID-19 case definitions in administrative and clinical databases


CNODES Virtual Seminar

June 1, 2022
Medication use in pregnancy: what can we really learn from real world evidence?

CNODES Virtual Seminar

May 11, 2022
Real-world data and cancer research in North Carolina: An introduction to the UNC Cancer Information and Population Health Resource (CIPHR)

CNODES Virtual Seminar

April 13, 2022
Opportunities & challenges of using Common Data Model in Europe: Experiences from BPE with SNDS French data. Presentation of ConcePTION CDM

CNODES Virtual Seminar

March 9, 2022
Surveillance of Adverse Infant Outcomes Following Maternal Medication Use During Pregnancy Using Tree-Based Scan Statistics