10 Jul Robert W. Platt
Bio
Robert Platt is a Professor in the department Epidemiology, Biostatistics, and Occupational Health (EBOH) at McGill University. He holds the Albert Boehringer I endowed chair in Pharmacoepidemiology.
Professor Platt is (effective December 2016) the Executive Co-Lead of CNODES. He has been the leader of the Methods team of CNODES since its inception. In this role, he has led a methods research and training program for the network and has participated as methods liaison (senior methods author) in numerous CNODES studies.
After completing his PhD in Biostatistics at the University of Washington in 1996, he joined the faculty at McGill University. His main research interests are statistical methods and applications for administrative data, pharmacoepidemiology, perinatal epidemiology, and methods for causal inference from epidemiological studies. His methodological interests center on marginal structural models for analyses of large administrative data cohorts, in particular the specification and optimization of the propensity score and inverse probability weights.
Professor Platt is principal investigator on a number of notable grants, including a Foundation Grant from the Canadian Institutes of Health Research (CIHR) and a Discovery Grant from the Natural Sciences and Engineering Council of Canada. He is co-investigator/subcontractor on several other CIHR and National Institutes of Health grants. In 2005, Prof. Platt received the Prix d’Excellence from the Québec Foundation for Research on Children’s Diseases. Prof. Platt was a 2016 Thomson Reuters Highly-Cited Researcher, and held a Chercheur national (national research scholar) award from the Fonds de recherche en santé du Québec from 2012 to 2016.
Professor Platt is editor-in-chief of Statistics in Medicine, editor of the American Journal of Epidemiology, is on the editorial board of Pharmacoepidemiology and Drug Safety, and is Associate Editor of the International Journal of Biostatistics. He has published over 325 articles, one book and several book chapters on epidemiology.
CNODES Projects
Incretin based drugs and the risk of pancreatic cancer: international multicentre cohort study
Methods LeadPropensity score model overfitting led to inflated variance of estimated odds ratios
Collaborator, CPRDAssociation between incretin-based drugs and the risk of acute pancreatitis
Methods LeadA multicenter observational study of incretin-based drugs and heart failure
Methods LeadUse of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Methods LeadOccurrence of pregnancy and pregnancy outcomes during isotretinoin therapy
Methods LeadImpact of using concomitant conventional DMARDs on adherence to biologic DMARD treatment in rheumatoid arthritis: Multi-centre, population-based cohort study
Methods LeadComparison of pregnancy outcomes of patients treated with ondansetron vs alternative antiemetic medications in a multinational, population-based cohort
Utilization and adverse outcomes of fluconazole during pregnancy
Methods LeadEstimating inverse probability weights using super learner when weight-model specification is unknown in a marginal structural Cox model context
Collaborator, CPRDEffect estimation in point-exposure studies with binary outcomes and high-dimensional covariate data – a comparison of targeted maximum likelihood estimation and inverse probability of treatment weighting
Project Lead, CPRDComparison of statistical approaches dealing with time-dependent confounding in drug effectiveness studies
Collaborator, Coordinating CenterOn the role of marginal confounder prevalence – implications for the high-dimensional propensity score algorithm
Collaborator, CPRDContour plot assessment of meta-analyses: robust association of statins-use and acute kidney injury risk
Collaborator, CPRDStatistical power in parallel group point exposure studies with time-to-event outcomes: an empirical comparison of the performance of randomized controlled trials and the inverse probability of treatment weighting (IPTW) approach
Collaborator, CPRDNetwork meta-analysis incorporating randomized controlled trials and non-randomized comparative cohort studies for assessing the safety and effectiveness of medical treatments: challenges and opportunities
Collaborator, CPRDObservational studies of drug safety in multi-database studies: Methodological challenges and opportunities
Project Lead, CPRDApplying targeted maximum likelihood estimation to pharmacoepidemiology
Corresponding Author, CPRDCNODES simulated data platform
Corresponding AuthorMeta-analysis/Bayesian stopping rules
CollaboratorAddressing confounding through extreme cohort restriction in large datasets: CNODES analysis of PPIs and pneumonia
CollaboratorCan we train machine learning methods to outperform the high-dimensional propensity score algorithm?
Project Lead, CPRDImproved matching performance by conditional caliper matching
Corresponding AuthorThe simulation of meta-analyses
Corresponding AuthorMajor bleeding in users of direct oral anticoagulants in atrial fibrillation: A pooled analysis of results from multiple population-based cohort studies
Methods LeadHydrochlorothiazide use and risk of keratinocyte carcinoma and melanoma: A multisite population-based cohort study
Methods LeadValsartan, Losartan and Irbesartan use in the USA, UK, Canada and Denmark after the nitrosamine recalls: a descriptive cohort study
Project LeadWeighted estimation for confounded binary outcomes subject to misclassification
Collaborator, CPRDExtreme restriction design as a method for reducing confounding by indication in pharmacoepidemiologic research
Collaborator, CPRDMultiple imputation for systematically missing confounders within a distributed data drug safety network: A simulation study and real-world example
Collaborator, CPRDPatterns of steroid utilization in COVID-19 patients
Project Co-LeadRisk of Arterial and Venous Thrombotic Events Among Patients with COVID-19: A Multi-National Collaboration of Regulatory Agencies from Canada, Europe, and United States
Project Co-LeadAtypical antipsychotics and cardiomyopathy: a population-based cohort study
Project Co-Lead, Coordinating CenterLikelihood ratio meta-analysis: New motivation and approach for an old method
Collaborator, CPRDThe use of atypical antipsychotics and the risk of breast cancer
Co-Site Investigator, QuebecThe use of atypical antipsychotics and the risk of breast cancer
Co-Site Investigator, QuebecUse of proton pump inhibitors and development of acute myocardial infarction
Co-Site Investigator, QuebecProton pump inhibitors and the risk of Clostridium difficile infection
Co-Site Investigator, Quebec