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Reviewing the effects of thiazide and thiazide-like diuretics as photosensitizing drugs on the risk of skin cancer
This project was a critical appraisal of the association between use of thiazide and thiazide-like diuretics and risk of skin cancer.
Q18-05Fluoroquinolone use for acute bacterial sinusitis
Fluoroquinolone antibiotic use was not associated with better clinical outcomes compared with other antibiotics among patients treated for acute bacterial sinusitis. Although a relatively small proportion of acute bacterial sinusitis events were treated with fluoroquinolones, guidelines suggest limiting their use to second-line treatment only.
Q16-02BCan we train machine learning methods to outperform the high-dimensional propensity score algorithm?
This study compares covariate selection strategies for confounding adjustment in secondary database analyses via Plasmode simulation: high-dimensional propensity score, machine learning algorithms: lasso, elastic net, random forest, etc.
Weighted estimation for confounded binary outcomes subject to misclassification
We introduce an inverse probability weighted approach to rebalance covariates across treatment groups while mitigating the influence of differential misclassification bias.
Changes in the dispensing of opioid medications in Canada following the introduction of a tamper-deterrent formulation of long-acting oxycodone: a time series analysis
This large, nationally representative study of opioid prescription patterns suggest that the introduction of a tamper-deterrent formulation of long-acting oxycodone, against a background of changes in public drug benefit policy, was associated with statistically significant, sustained changes in selection of long-acting opioids but only modest changes in the quantities of long-acting opioids dispensed.
Q13-03BComparative safety of direct oral anticoagulants and warfarin in patients with venous thromboembolism: a multicenter observational study of administrative databases
Among venous thromboembolism patients, treatment with DOACs when compared to warfarin is not associated with an increased risk for major bleeding or all-cause mortality.