Utilization and adverse outcomes of fluconazole during pregnancy (Q16-09)

Utilization and adverse outcomes of fluconazole during pregnancy (Q16-09)

Q16-09

Overview

What was the issue?
  • Oral azoles are not recommended during pregnancy due to concerns about birth defects, particularly with higher doses. The fetal safety of oral fluconazole remains poorly understood.
What was the aim of the study?
  • To assess whether use of oral fluconazole during pregnancy is associated with fetal death and major congenital malformation, relative to use of topical azoles.

Manuscripts

Dormuth CR, Winquist B, Fisher A, Wu F, Reynier P, Suissa S, Dahl M, Ma Z, Lu X, Zhang J, Raymond CB, Filion KB, Platt RW, Moriello C, Paterson JM, for the Canadian Network for Observational Drug Effect Studies (CNODES) Investigators. Comparison of Pregnancy Outcomes of patients treated with Ondansetron versus Alternative antiemetic medications in a multinational, population-based cohort. JAMA Netw Open. 2021 Apr 1;4(4):e215329.

Presentations

Project Team

Project Co-Lead
Michael Paterson MSc
Project Co-Lead
Colin R. Dormuth ScD
Methods Lead
Robert W. Platt PhD
Content Expert
Brandace Winquist
Lead Analyst
Fangyun Wu MSc
Research Assistant
Carolina Moriello MSc
Site Investigator
MarketScan
Site Investigator
Brandace Winquist
Saskatchewan
Site Investigator
Michael Paterson MSc
Ontario
Site Investigator
Kristian Filion PhD
CPRD
Site Investigator
Jianguo (James) Zhang MSc
Alberta
Site Investigator
Colin R. Dormuth ScD
British Columbia
Analyst
Anat Fisher MD, PhD
MarketScan
Analyst
Xinya Lu PhD
Saskatchewan
Analyst
Fangyun Wu MSc
Ontario
Analyst
Matthew Dahl BSc
Manitoba
Analyst
Pauline Reynier Msc
CPRD
Analyst
Anat Fisher MD, PhD
British Columbia
Analyst
Alberta