15 Aug Utilization and adverse outcomes of fluconazole during pregnancy (Q16-09)
Utilization and adverse outcomes of fluconazole during pregnancy (Q16-09)
What was the issue?
- Oral azoles are not recommended during pregnancy due to concerns about birth defects, particularly with higher doses. The fetal safety of oral fluconazole remains poorly understood.
What was the aim of the study?
- To assess whether use of oral fluconazole during pregnancy is associated with fetal death and major congenital malformation, relative to use of topical azoles.
Dormuth CR, Winquist B, Fisher A, Wu F, Reynier P, Suissa S, Dahl M, Ma Z, Lu X, Zhang J, Raymond CB, Filion KB, Platt RW, Moriello C, Paterson JM, for the Canadian Network for Observational Drug Effect Studies (CNODES) Investigators. Comparison of Pregnancy Outcomes of patients treated with Ondansetron versus Alternative antiemetic medications in a multinational, population-based cohort. JAMA Netw Open. 2021 Apr 1;4(4):e215329.