CNODES Training Newsletter
June 2019

Liliya Sinyavskava, University of Montreal

Liliya Sinyavskaya is pursuing a doctorate in Medical Science with a concentration in pharmacoepidemiology at the University of Montreal. Liliya’s research on direct oral coagulants (DOACs) for people with atrial fibrillation has contributed significantly to the work of the CNODES methods team. She recently received a doctoral grant from the Fonds de la recherche en santé du Québec (FRSQ). Liliya agreed to answer a few questions about her research and her experiences related to CNODES.

"My research explores the impact of methodological issues in the context of an important clinical question. Results of the previous observational studies can be reappraised based on our findings, and some heterogeneity can be explained. The findings can also be extrapolated to other clinical questions."

Read the full interview with Liliya and see other profiles on the Trainee Profiles page

If you are a CNODES trainee and would like to see yourself and your research profiled here, please email us at
CNODES Analyst Training Program Update

As mentioned in previous newsletters, the CNODES Training Team is currently developing an Analyst Training Program. Online training modules will walk learners through the interpretation and implementation of a pharmacoepidemiology statistical analysis plan, and will provide hands-on learning using simulated datasets. Topics will cover SAS coding, working with administrative health data, statistical methods, and pharmacoepidemiology. We hope our training materials will be useful for students and analysts working in other organizations who conduct drug safety and effectiveness research.

The Content Development Team, composed of CNODES analysts and volunteers, began work this spring and is making great progress developing these online modules. We welcome new volunteers who are interested in creating or reviewing content for the program. Please e-mail to learn about how you can get involved. We look forward to hearing from you.
Webinar | The Canadian Mother-Child Cohort Initiative

CIHR's Drug Safety and Effectiveness Cross-Disciplinary Training Program (DSECT) Monthly Seminar Series featured the presentation “The Canadian Mother-Child Cohort initiative” by Dr. Anick Bérard, Professor, Faculty of Pharmacy, University of Montreal on May 23, 2019. A recording of the presentation is now available for viewing. View the recorded presentation.

Additional webinars sponsored by the Drug Safety and Effectiveness Cross-Disciplinary Training Program (DSECT) are also available on the DSECT website.
Webinar | Diclofenac Use and Cardiovascular Risks

The Danish Society for Pharmacoepidemiology hosts a series of webinars on "hot topics." A recent webinar features Dr. Morten Schmidt, first author of the 2018 British Medical Journal (BMJ) article "Diclofenac use and cardiovascular risks: series of nationwide cohort studies."  Dr. Morten presents the research findings from this series of 252 cohort studies across Denmark which examined the cardiovascular risks of diclofenac compared with non-steroidal anti-inflammatory drugs, paracetamol, and no drug treatment. View the recorded webinar. And check out the other Hot Topic Webinars on the Society's website.
Submissions Wanted | ISPE Manuscript Project 2019

The International Society for Pharmacoepidemiology (ISPE) seeks proposals for manuscripts that could be used for guideline development or reference documents for pharmacoepidemiology, including pharmacovigilance, drug utilization research, outcomes research, comparative effectiveness research, and therapeutic risk management. Deadline for submissions is September 27, 2019. Read the call for submissions.
Podcast | Network Meta-analyses of Antidepressants

Dr. Andrea Cipriani, NIHR Research Professor at the Department of Psychiatry, University of Oxford, hosts the podcast "The role of network meta-analysis in the evaluation of antidepressants for depression." Specifically, the podcast focuses on "network meta-analysis and individual patient data meta-analysis, trying to assess the validity, breadth, structure and interpretation of statistical approaches to better inform the mental healthcare decision-making process." Listen to the podcast.
Panel Presentation | Taking Action on Real World Evidence

The Canadian Association for Population Therapeutics (CAPT) hosted a panel presentation as an introductory session of the 2018 Annual Conference entitled "Taking Action on Real World Evidence: From Analysis to Impact." The panel members represented multiple stakeholders and set the stage for discussions at the conference about current practices and future opportunities for real world evidence in the Canadian context. View the recorded session.  
Fellowships | Banting Postdoctoral Fellowship Competition

The Canadian Institutes for Health Research (CIHR) Banting Postdoctoral Fellowships provide $70,000 per year for two years. The program is open to both Canadian and international researchers who have recently completed a PhD (or equivalent), or health professional degree. Applications must be completed in full collaboration with the proposed host institution. The 2019-2020 competition application deadline is September 18, 2019 (Note that institutions may have internal deadlines). For more information, see the Government of Canada website or email
Postdoctoral Scholarship | Vanier Canada Graduate Scholarship 

The Vanier Canada Graduate Scholarship provides funding for doctoral students. Valued at $50,000 per year for three years during doctoral studies. Scholarships are provided based on academic excellence, research potential, and leadership. Candidates must be nominated by a Canadian institution where they wish to study. The 2019-20 competition for this scholarship is expected to be launched in June 2019. Learn more.
Call for Input | CIHR Strategic Plan 2020-2025

The Canadian Institutes of Health Research (CIHR) are developing their 2020–2025 strategic plan and are seeking input on how best to spend the research funding budget. To provide your ideas on research priorities, complete a survey and/or post a comment or question to the discussion forum. Visit CIHR's Let's Talk website for more information.

For more information about other CIHR funding opportunities see the CIHR Funding Opportunity Database
PhD Posting | University of Manitoba

Dr. Silvia Alessi-Severini, Associate Professor in the College of Pharmacy at the University of Manitoba, is currently seeking a PhD student to join her research program. Candidates with an MSc in Pharmacy or other disciplines such as Health Sciences, Pharmacoepidemiology, or Biostatistics will be considered. Knowledge of SAS statistical software is an asset. Current project: a pharmacoepidemiologic study looking at the use, safety and effectiveness of medications for the treatment of hepatitis C infection. Email Dr. Silvia Alessi-Severini for more information and to apply.
Postdoctoral Fellow Posting | University of British Columbia

Dr. Colin Dormuth, Associate Professor, Department of Anesthesiology, Pharmacology & Therapeutics, University of British Columbia is currently seeking a postdoctoral fellow to join his research team at the Pharmacoepi Group of the Therapeutics Initiative. Candidates who have recently graduated with a PhD in Statistics, Biostatistics, Epidemiology, or a related field will be considered. The candidate will have a strong foundation in statistics, and experience coding in SAS. Experience in pharmacoepidemiology would be an asset. The candidate will work on multiple pharmacoepi projects, including an analysis of the effectiveness of medication safety advisories. Email Julie Teng for more information and to apply.
Preprint Service | medRxiv Preprint Server for the Health Sciences

medRxiv logomedRxiv (pronounced “med-archive”) is a free, non-profit preprint service for clinical researchers to submit manuscripts before they are peer reviewed or published in journals. This service facilitates early dissemination of research findings and the opportunity for feedback to improve manuscripts prior to publication in academic journals. medRxiv is a collaborative initiative of the Cold Spring Harbor Laboratory, Yale University, and the British Medical Journal (BMJ). After submitting to medRxiv, manuscripts are assigned a digital object identifier (DOI), and authors have the option to remove manuscripts they no longer wish to store on the server. Learn more.
Presentation | TI Methods Speaker Series

TI logoAt the University of British Columbia, the Therapeutics Initiative Methods Speaker Series organized by Dr. Carole Lunny is using the Open Science Framework to collaborate and store recordings of presentations. A recent presentation by Dr. Oscar L. Olvera Astivia, University of South Florida, "The replication crisis and where is this all going" is now accessible through the OSF platform. You can attend the TI's speaker series presentations in person or remotely by video conference. Using the same platform, the TI also recently started a journal club and welcomes new members to join.
Presentation | 101 Innovations in Scholarly Communication

101 Innovations in Scholarly Communication is a project based at University of Utrecht in The Netherlands where researchers are charting the creation, availability, and usage of research tools. The project is part of an investigation into patterns of use and why certain tools are used and other are not. To learn more about the tools under investigation, visit the 101 Innovations website.
Assessment Tool | KT Pathways

KT Pathways is a free digital assessment and educational tool co-developed by the Michael Smith Foundation for Health Research (MSFHR) in British Columbia, and academic and health system partners. The tool allows anyone to assess their knowledge translation (KT) skills in comparison to a set of core KT skills linked to successful knowledge translation. To use the assessment tool, visit the KT Pathways website.
Course | Cochrane Interactive Learning Modules

Cochrane online learningThe Cochrane Interactive Learning is a self-directed online course, developed by Cochrane experts worldwide, which consists of 10 one-hour modules to learn the complete process of conducting a systematic review. The course is geared for both new and experienced review authors and is offered at reasonable cost. Learn more

Related resource: For a recent example of the applicability of systematic reviews in clinical epidemiology, see the recent publication in the Journal of Clinical Epidemiology:  Johnston A, Kelly SE, Hsieh S, Skidmore B, Wells GA. Systematic reviews of clinical practice guidelines: a methodological guide. Journal of Clinical Epidemiology. 2019;108:64-76.
Open Access Journal | PeerJ Open Access Journals

PeerJ is a hub for open access journals that has been in operation for 6 years. The mission of PeerJ is "to make Open Access affordable, fast, and easier for researchers and institutions." You can become a peer reviewer and/or submit a draft manuscript or final version of your work to PeerJ Preprint. Visit the PeerJ website for a list of journals and more information.
Open Science | Open Science MOOC

Open Science MOOC (massive open online course) began in 2017 following an Open Science conference in Berlin, Germany and the online community has been building ever since. This MOOC is being developed as 10 course modules designed for students and researchers to build skills and share online tools in a rapidly changing research environment. The project aims to increase "rigour, accountability, reproducibility for research" and is based on"the principles of inclusion, fairness, equity, and sharing." Open Science MOOC is mainly supported through the contributions of volunteers. If you would like to be part of the online community, you can sign up and/or join the GitHub production team. There is also a Slack channel and a blog on Open Science issues

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