CDM Projects

As part of a collaboration with International Coalition of Medicines Regulatory Authorities (ICMRA), we will replicate a study conducted by DARWIN EU to estimate background incidence rates of vaccine adverse events of special interest in Canada.

This project is a replication of our previous study. The main objective is to update information on contraception use, pregnancy occurrence, and pregnancy outcomes during isotretinoin therapy.

The objective of this pilot project is to determine the utilization of antidiabetic drugs among pregnant people living in Canada using CNODES' adaptation of the Sentinel Common Data Model.

Opioid use is a potential risk factor for diverticulitis. However, evidence on the association between opioid analgesics and diverticulitis is limited. The overall aim of this study is to evaluate the feasibility of, and subsequently conduct, an observational study evaluating whether short-term and sustained opioid use are associated with elevated risks of diverticulitis in patients indicated for treatment with opioids.

Further focused studies are necessary to establish the presence of meaningful safety signals of Ozempic. Our study provides important lessons for the future use of Canadian data in TreeScan-based analyses.

The current available real-world evidence on the potential association between GLP-1 receptor agonists and the risk of suicidality and self-harm is limited, as the studies had contradictory findings and important methodological limitations.