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Sodium glucose cotransporter 2 inhibitors and risk of major adverse cardiovascular events: multi-database retrospective cohort study
SGLT2 inhibitor use was associated with a decreased risk of serious cardiovascular events compared with the use of DPP-4 inhibitors among patients with type 2 diabetes.
Q18-06Sodium-glucose cotransporter-2 inhibitors and the risk for diabetic ketoacidosis: a multicenter cohort study
SGLT2 inhibitor use was associated with an increased risk of diabetic ketoacidosis compared to DPP-4 inhibitors among patients with type 2 diabetes.
Q18-11Identification of incident pancreatic cancer in Ontario administrative health data: A validation study
The purpose of this study was to validate three approaches for identifying incident cases of pancreatic cancer in Ontario administrative claims data.
Extreme restriction design as a method for reducing confounding by indication in pharmacoepidemiologic research
Confounding by indication is a concern in observational pharmacoepidemiologic studies, including those that use active comparator, new user (ACNU) designs. Here, we present a method of restriction to an indication, which we call "extreme restriction," to reduce confounding in such studies.
Multiple imputation for systematically missing confounders within a distributed data drug safety network: A simulation study and real-world example
We conducted a simulation study and a real-world analysis using the UK's Clinical Practice Research Datalink to evaluate multiple imputation for confounders that are systematically missing from a subset of data sites in mock distributed data networks.
Data variability across Canadian administrative health databases: Differences in content, coding, and completeness
In this study, we compare the provincial administrative databases and illustrate the potential impact of database differences on a CNODES study about domperidone and the risk of ventricular tachyarrhythmia and sudden cardiac death.