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Identification of incident pancreatic cancer in Ontario administrative health data: A validation study
The purpose of this study was to validate three approaches for identifying incident cases of pancreatic cancer in Ontario administrative claims data.
Extreme restriction design as a method for reducing confounding by indication in pharmacoepidemiologic research
Confounding by indication is a concern in observational pharmacoepidemiologic studies, including those that use active comparator, new user (ACNU) designs. Here, we present a method of restriction to an indication, which we call "extreme restriction," to reduce confounding in such studies.
Multiple imputation for systematically missing confounders within a distributed data drug safety network: A simulation study and real-world example
We conducted a simulation study and a real-world analysis using the UK's Clinical Practice Research Datalink to evaluate multiple imputation for confounders that are systematically missing from a subset of data sites in mock distributed data networks.
Data variability across Canadian administrative health databases: Differences in content, coding, and completeness
In this study, we compare the provincial administrative databases and illustrate the potential impact of database differences on a CNODES study about domperidone and the risk of ventricular tachyarrhythmia and sudden cardiac death.
Comparative effectiveness of fluoroquinolone antibiotic use in uncomplicated acute exacerbations of chronic obstructive pulmonary disease: a multi-cohort study
There is no apparent benefit in short-term clinical outcomes with fluoroquinolones compared with other antibiotics for the treatment of uncomplicated acute exacerbations of COPD. These findings support current recommendations that fluoroquinolone antibiotics should be reserved for treatment of severe exacerbations of COPD.
Q16-02CFluoroquinolone use for uncomplicated urinary tract infections in women: a retrospective cohort study
Fluoroquinolone antibiotic use was associated with a modest reduction in short-term clinical outcomes compared with other antibiotics among women with uncomplicated urinary tract infections (UTIs). The modest benefit of fluoroquinolone antibiotics should be weighed against risk of rare but severe adverse effects of fluoroquinolones when clinicians are selecting first line treatment for women with uncomplicated UTIs.