-
Data variability across Canadian administrative health databases: Differences in content, coding, and completeness
In this study, we compare the provincial administrative databases and illustrate the potential impact of database differences on a CNODES study about domperidone and the risk of ventricular tachyarrhythmia and sudden cardiac death.
Identification of incident pancreatic cancer in Ontario administrative health data: A validation study
The purpose of this study was to validate three approaches for identifying incident cases of pancreatic cancer in Ontario administrative claims data.
Comparative effectiveness of fluoroquinolone antibiotic use in uncomplicated acute exacerbations of chronic obstructive pulmonary disease: a multi-cohort study
There is no apparent benefit in short-term clinical outcomes with fluoroquinolones compared with other antibiotics for the treatment of uncomplicated acute exacerbations of COPD. These findings support current recommendations that fluoroquinolone antibiotics should be reserved for treatment of severe exacerbations of COPD.
Q16-02CFluoroquinolone use for uncomplicated urinary tract infections in women: a retrospective cohort study
Fluoroquinolone antibiotic use was associated with a modest reduction in short-term clinical outcomes compared with other antibiotics among women with uncomplicated urinary tract infections (UTIs). The modest benefit of fluoroquinolone antibiotics should be weighed against risk of rare but severe adverse effects of fluoroquinolones when clinicians are selecting first line treatment for women with uncomplicated UTIs.
Q16-02AReviewing the effects of thiazide and thiazide-like diuretics as photosensitizing drugs on the risk of skin cancer
This project was a critical appraisal of the association between use of thiazide and thiazide-like diuretics and risk of skin cancer.
Q18-05Fluoroquinolone use for acute bacterial sinusitis
Fluoroquinolone antibiotic use was not associated with better clinical outcomes compared with other antibiotics among patients treated for acute bacterial sinusitis. Although a relatively small proportion of acute bacterial sinusitis events were treated with fluoroquinolones, guidelines suggest limiting their use to second-line treatment only.