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Network meta-analysis incorporating randomized controlled trials and non-randomized comparative cohort studies for assessing the safety and effectiveness of medical treatments: challenges and opportunities
We review issues in network meta-analysis, specifically related to the incorporation of observational data.
Statistical power in parallel group point exposure studies with time-to-event outcomes: an empirical comparison of the performance of randomized controlled trials and the inverse probability of treatment weighting (IPTW) approach
We compare the statistical power of an observational study using an IPTW design with that of a randomized controlled trial.
Serotonin-norepinephrine reuptake inhibitors and the risk of AKI: A cohort study of eight administrative databases and meta-analysis
This study found that using serotonin-norepinephrine reuptake inhibitors (SNRIs) is not associated with an increased risk of hospitalization for acute kidney injury (AKI), when compared to selective serotonin reuptake inhibitors (SSRIs).
Q12-08Contour plot assessment of meta-analyses: robust association of statins-use and acute kidney injury risk
We propose an extended contour approach for the graphical assessment of the robustness of meta-analyses results with applications to data on statins use and kidney injury.
On the role of marginal confounder prevalence – implications for the high-dimensional propensity score algorithm
We apply the law of total probability in conjunction with an established bias formula to derive and illustrate relative bias boundaries with respect to marginal confounder prevalence.
Retrospective analysis of trends in dispensing of long-acting non-tamper-deterrent oxycodone near the USA-Canada border
Our population-based analysis of all long-acting oxycodone dispensed in Canadian pharmacies near the Canada–US border found no evidence of behaviour suggestive of large-scale trafficking of generic non–tamper-resistant formulations after their introduction in Canada. However, Canadian clinicians and pharmacists should remain cautious in their prescribing and dispensing because of the high potential for misuse and abuse of this medication.