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Association between incretin-based drugs and the risk of acute pancreatitis
The use of incretin-based drugs was not associated with an overall increased risk of pancreatitis, compared with other oral antidiabetic drugs.
Q13-06AComparison of statistical approaches dealing with time-dependent confounding in drug effectiveness studies
We carry out simulation studies to assess the suitability of the 'sequential Cox approach' for analyzing time-to-event data in the presence of a time-dependent confounder, as an alternative to the marginal structural Cox modelling approach.
Utilization and adverse outcomes of fluconazole during pregnancy
In this large study of 4,103,700 pregnant women, fluconazole use during pregnancy was associated with an increased risk of fetal death, but not congenital malformation, relative to use of vaginal azole antifungals.
Q16-09Ventricular tachyarrhythmia and sudden cardiac death with domperidone use in Parkinson’s Disease
Current use of domperidone may increase the risk of ventricular tachyarrhythmia and sudden cardiac death (VT/SCD) in patients with Parkinson’s disease, particularly those with a history of cardiovascular disease.
Q13-02Occurrence of pregnancy and pregnancy outcomes during isotretinoin therapy
There is low compliance to the isotretinoin pregnancy prevention program in Canada.
Q10-23Applying targeted maximum likelihood estimation to pharmacoepidemiology
We illustrate the practical implementation of a newly proposed double robust estimator “Targeted Maximum Likelihood Estimation” (TMLE) and demonstrated its application in common pharmacoepidemiological settings. A real-word example using the clinical practice research datalink is used with a high-dimensional covariate space.