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Validity of diagnoses of SARS-CoV-2 infection in Canadian administrative health data: a multiprovince, population-based cohort study
This multi-province validation study supports the use of inpatient and ED records as alternatives to population- based laboratory tests for identification of COVID-19 cases during the first year of the pandemic.
Our findings do not support the use of outpatient service claims to identify people infected with COVID-19.Q21-04Hydrochlorothiazide use and risk of keratinocyte carcinoma and melanoma: A multisite population-based cohort study
The use of hydrochlorothiazide (HCTZ) was not associated with increased overall risks of keratinocyte carcinoma or melanoma when compared with angiotensin-converting enzyme inhibitors (ACEIs). However, elevated risks of keratinocyte carcinoma and melanoma were observed with longer durations of use (≥10 years) and higher cumulative doses (≥100,000 mg) of HCTZ, particularly when compared with calcium channel blockers (CCBs).
Q19-05Valsartan, Losartan and Irbesartan use in the USA, UK, Canada and Denmark after the nitrosamine recalls: a descriptive cohort study
In Canada, an immediate steep decline in valsartan use was observed after the July 2018 recall accompanied by increased switching to other angiotensin receptor blocker (ARB) products. Subsequent recalls for losartan and irbesartan were also associated with increased switching, but overall trends in use remained unchanged. Despite availability of uncontaminated ARB products at the time of the recall, findings show that the immediate response was to switch patients to another ARB.
Q20-02_CDMComparison of pregnancy outcomes of patients treated with ondansetron vs alternative antiemetic medications in a multinational, population-based cohort
In this large study of 4,103,695 pregnancies, ondansetron use during pregnancy was not associated with increased risks of fetal death, spontaneous abortion, stillbirth, or major congenital malformation, when compared with other commonly used antiemetic drugs.
Q16-08Patterns of steroid utilization in COVID-19 patients
This population-based study of COVID-19 outpatients in three Canadian provinces, demonstrated that use of systemic corticosteroid therapy as a treatment for COVID-19 was limited during the first year of the pandemic.
Q21-02_CDMMajor bleeding in users of direct oral anticoagulants in atrial fibrillation: A pooled analysis of results from multiple population-based cohort studies
This international, multi-center, retrospective cohort, confirmed that the risk of major bleeding associated with direct oral anticoagulants as a class is not increased compared to vitamin K antagonists. Furthermore, the study observed a modest increased risk of major bleeding with rivaroxaban, and a lower risk with apixaban and dabigatran.