Methods Projects

We illustrate the practical implementation of a newly proposed double robust estimator “Targeted Maximum Likelihood Estimation” (TMLE) and demonstrated its application in common pharmacoepidemiological settings. A real-word example using the clinical practice research datalink is used with a high-dimensional covariate space.

The use of incretin-based drugs was not associated with an overall increased risk of pancreatitis, compared with other oral antidiabetic drugs.

We describe how three different propensity score methods, propensity score matching, stratification on the propensity score and inverse probability of treatment weighting using the propensity score, can be used to estimate absolute measures of treatment effect on survival outcomes.

We carry out simulation studies to assess the suitability of the 'sequential Cox approach' for analyzing time-to-event data in the presence of a time-dependent confounder, as an alternative to the marginal structural Cox modelling approach.

In this large study of 4,103,700 pregnant women, fluconazole use during pregnancy was associated with an increased risk of fetal death, but not congenital malformation, relative to use of vaginal azole antifungals.

Current use of domperidone may increase the risk of ventricular tachyarrhythmia and sudden cardiac death (VT/SCD) in patients with Parkinson’s disease, particularly those with a history of cardiovascular disease.