Fluoroquinolone use and acute bacterial sinusitis (Q16-02B)
- Systemic oral fluoroquinolones are among the most widely prescribed class of antibiotics and are associated with potential harmful side effects. Their use has been expanding to milder infections, such as acute bacterial sinusitis (ABS), with limited evidence of superiority to first line antibiotics.
Aims of the study
- To compare repeat primary care visits and subsequent antibiotic dispensations within 30 days after initial antibiotic dispensation for ABS treated with a fluoroquinolone versus other antibiotics (e.g., amoxicillin, amoxicillin/clavulanate).
St-Jean A, Chateau D, Dahl M, Ernst P, Daneman N, Sketris IS, Zhang J, Marra F, Quail J, Bugden S, for the Canadian Network for Observational Drug Effect Studies (CNODES) Investigators. Regional Variation in the Potentially Inappropriate First Line Use of Fluoroquinolones in Canada as a Key to Antibiotic Stewardship? A Drug Utilization Review Study. BMC Infectious Diseases. 2021 Aug 3;21(1):733.
Ernst P, Dahl M, Chateau D, Daneman N, Quail J, Sketris IS, Fisher A, Zhang J, Bugden S for the Canadian Network for Observational Drug Effect Studies (CNODES) Investigators. Comparative effectiveness of fluoroquinolone antibiotic use in uncomplicated acute exacerbations of COPD: A multi-cohort study. International Journal of Chronic Obstructive Pulmonary Disease. 2019 Dec 18, 14: 2939—2946
Daneman N, Chateau D, Dahl M, Zhang J, Fisher A, Sketris IS, Quail J, Lalji F, Ernst P, Bugden S; for the Canadian Network for Observational Drug Effect Studies (CNODES) Investigators. Fluoroquinolone Use for Uncomplicated Urinary Tract Infections in Women: A Retrospective Cohort Study. Clinical Microbiology and Infection.2020 May;26(5):613-618.