Fluoroquinolone use and acute bacterial sinusitis (Q16-02B)

Fluoroquinolone use and acute bacterial sinusitis (Q16-02B)

Q16-02B

Overview

Background
  • Systemic oral fluoroquinolones are among the most widely prescribed class of antibiotics and are associated with potential harmful side effects. Their use has been expanding to milder infections, such as acute bacterial sinusitis (ABS), with limited evidence of superiority to first line antibiotics.
Aims of the study
  • To compare repeat primary care visits and subsequent antibiotic dispensations within 30 days after initial antibiotic dispensation for ABS treated with a fluoroquinolone versus other antibiotics (e.g., amoxicillin, amoxicillin/clavulanate).

Manuscripts

St-Jean A, Chateau D, Dahl M, Ernst P, Daneman N, Sketris IS, Zhang J, Marra F, Quail J, Bugden S, for the Canadian Network for Observational Drug Effect Studies (CNODES) Investigators. Regional Variation in the Potentially Inappropriate First Line Use of Fluoroquinolones in Canada as a Key to Antibiotic Stewardship? A Drug Utilization Review Study. BMC Infectious Diseases. 2021 Aug 3;21(1):733.

Ernst P, Dahl M, Chateau D, Daneman N, Quail J, Sketris IS, Fisher A, Zhang J, Bugden S for the Canadian Network for Observational Drug Effect Studies (CNODES) Investigators. Comparative effectiveness of fluoroquinolone antibiotic use in uncomplicated acute exacerbations of COPD: A multi-cohort study. International Journal of Chronic Obstructive Pulmonary Disease. 2019 Dec 18, 14: 2939—2946

Daneman N, Chateau D, Dahl M, Zhang J, Fisher A, Sketris IS, Quail J, Lalji F, Ernst P, Bugden S; for the Canadian Network for Observational Drug Effect Studies (CNODES) Investigators. Fluoroquinolone Use for Uncomplicated Urinary Tract Infections in Women: A Retrospective Cohort Study. Clinical Microbiology and Infection.2020 May;26(5):613-618.

Presentations

Project Team

Methods Lead
Dan Chateau PhD
Steering Committee Liaison
Pierre Ernst MD, MSc, FRCPC
Lead Analyst
Matthew Dahl BSc
Research Assistant
Audray St-Jean MSc
Site Investigator
Jianguo (James) Zhang MSc
Alberta
Site Investigator
Fawziah Lalji BSC(PHARM), PHARMD, FCSHP
British Columbia
Site Investigator
Shawn C. Bugden BSc (Pharm), MSc, PharmD
Manitoba
Site Investigator
Ingrid Sketris Pharm D, MPA(HSA)
Atlantic
Site Investigator
Hala Tamim PhD
Atlantic
Site Investigator
Nick Daneman MD, FRCPC, MSc
Ontario
Site Investigator
Mikhael Laskine
Quebec
Site Investigator
Jacqueline Quail PhD
Saskatchewan
Analyst
Zhihai Ma
Alberta
Analyst
Anat Fisher MD, PhD
British Columbia
Analyst
Matthew Dahl BSc
Manitoba
Analyst
Yan Wang MSc
Atlantic
Analyst
Steve Doucette MSc
Atlantic
Analyst
Vicki Ling
Ontario
Analyst
Fangyun Wu MSc
Ontario
Analyst
Yu Lan Jin BA, MA
Quebec
Analyst
Nianping Hu PhD
Saskatchewan