04 Jun Methadone containing products used for opioid use disorder (Q20-20)
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Methadone containing products used for opioid use disorder (Q20-20)
Q20-20
Overview
What is the issue?
- Methadone is used for the treatment of opioid use disorder.
- In 2014/2015, most Canadian public drug plans transitioned from the existing 1mg/ml pharmacist-compounded formulation to Methadone 10 mg/ml, a more stable pre-mixed formulation. Subsequent to this policy change, there has been reports that some patients may experience decreased effectiveness with the newer methadone formulation.
- There is a need to better understand whether switching from one methadone-containing to another is associated with changes in measures of drug effectiveness or safety.
What was the aim of the study?
- The study objective is to determine the proportion of patients who experience safety outcomes when switching from compounded methadone, Methadose or Metadol-D to another formulation or brand, and the short-term outcomes in these patients.
What did the study find?
- This project was deemed not feasible.